Effect Of Different Calcium Channel Blockers on Gastric Ulcers - Effect Of Calcium Channel Blockers On Ulcers
by Jha, Shailendra Kumar
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Background & Objective: Since calcium has got importance in physiology and the objective of the present study is to study the effect of different calcium channel blockers through i.c.v administration on gastric and duodenal ulcers. Methods: The effect of different calcium channel blockers on gastric and duodenal ulcers were evaluated by using different experimental models such as acetic acid induced chronic gastric ulcer, pylorus ligation induced gastric ulcers, ethanol induced gastric ulcers, stress induced gastric ulcers, and cysteamine induced duodenal ulcers. In all these models the common parameter determined was ulcer index. Results: The nickel salt and verapamil a significant effect on ulcer healing in acetic acid induced ulcer model, -agatoxin did not show any significant effect on ulcer healing. The treatment groups showed a significant reduction in ulcer index in other models. Only -agatoxin did not showed significant increase in mucin compared to other treatment groups.
Jha, Shailendra Kumar
Harshadrai, Merai Ankit
Mr. Shailendra Kumar Jha, M. Pharmacy working as an Asst. Manager in Clinical Research at Ajanta Pharma Ltd, Mumbai. AND Mr. Merai Ankit Harshadrai, M. Pharmacy (Ph.D ) working as Asst. Prof. in the subject of pharmacology at Smt. BNBSP College, Vapi, India.
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LAP Lambert Academic Publishing
31 January 2012
0.22 x 0.15 x 0.003 m; 0.132 kg