Role of Proteases in Cellular Dysfunction

by Springer US
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£164.72
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Springer US Role of Proteases in Cellular Dysfunction
Springer US - Role of Proteases in Cellular Dysfunction

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Description

It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues.


Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.

Further information

Illustrations Note:
12 SW-Abb., 46 Farbabb., 29 Tabellen
remarks:

First volume to comprehensively explore the role of proteases in various diseases


Provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development


Utilizes a multidisciplinary approach to biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases

Media Type:
Buch gebunden
Publisher:
Springer US
Biography Artist:

Sajal Chakraborti is a professor at the University of Kalyani, India.


Naranjan S. Dhalla is a professor at St. Boniface General Hospital  and the University of Manitoba, Canada.

Language:
Englisch
Number of Pages:
462
summary:
This volume explores the role of proteases in various diseases. It provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development.

Master Data

Product Type:
Hardback book
Release date:
10 December 2013
Package Dimensions:
0.234 x 0.16 x 0.03 m; 0.861 kg
GTIN:
09781461490982
DUIN:
53LEMQASVRM
Manufacturer Part Number:
12 black & white illustrations
£164.72
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