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In this work a novel multi-purpose platform for the
three-dimensional cultivation of cells is described,
its main component being a polymer chip (CellChip)
that features a microstructured area of 1-2cm2.
The microstructured area is realized as a grid of
micro-containers measuring 300µm in depth, length
and height. Depending on the cells and the chip type
used up to 7 106 cells can be cultivated on one chip.
For the facilitation of nutrient and oxygen supply
the CellChip can be inserted into a bioreactor
housing that can be tailored to the specific
application. For drug screening and other high-
throughput purposes a bioreactor with microtiter
plate-footprint was developed in this work. Up to 12
CellChips can be incorporated into this bioreactor
with independent nutrient and oxygen supply.


Author Gerald Zimmer

Product Details


GTIN 9783639105414

Language English

Pages 92

Product type Paperback

Development of a CellChip based Multi-Well-Type Bioreactor

A multi-purpose platform for three dimensional cultivation of cells

Gerald Zimmer

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