IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER

by Patil, Shankargouda
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Patil, Shankargouda IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER
Patil, Shankargouda - IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER

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Description

The expression of simple epithelial cytokeratins 8 and 18 is normally seen in the embryonic cells and lost in adult squamous epithelium. CK 8 and 18 play a role in tumor progression and metastatic potential as these are expressed only in the poorly differentiated and not in well differentiated squamous cell carcinomas. It appears that increased expression of the embryonic or simple epithelial cytokeratins 8 and 18 in some way changes the phenotypic characteristics of stratified epithelial cells, resulting in malignant transformation. Presence of Cytokeratin 8 and 18 in poorly differentiated foci of Oral squamous cell carcinoma even in the absence of metastasis could indicate a poor prognosis in these patients. However they are of functional importance in malignancy of keratinocytes and could be related to tumor invasion and/or to changes in epithelial mesenchymal interactions.

Contributors

Author:
Patil, Shankargouda

Further information

Media Type:
Softcover
Publisher:
LAP Lambert Academic Publishing
Biography Artist:
Presently Working as Asst.Professor,Dept of Oral Pathology in KLE Society s Institute of Dental Sciences,Bangalore. Secretary, International Association of General Dentistry, Texas/ Bangalore Managing Editor World Journal of dentistry Advisory board member for Guident Magazine Editorial board member in the Journal of International Oral Health
Language:
English
Number of Pages:
108

Master Data

Product Type:
Paperback book
Release date:
7 September 2010
Package Dimensions:
0.216 x 0.15 x 0.02 m; 0.068 kg
GTIN:
09783843352178
DUIN:
DN886G9AB6I
£40.99
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