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Effects of INFV in aged mice and anti-M2 antibody on different strains

by Muto, Nilton
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Muto, Nilton Effects of INFV in aged mice and anti-M2 antibody on different strains
Muto, Nilton - Effects of INFV in aged mice and anti-M2 antibody on different strains

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Delivery: between 2021-04-23 and 2021-04-27
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Description


In¿uenza A viruses cause yearly seasonal epidemics resulting in a global burden of ~500,000 deaths every year. They are classi¿ed by their surface hemagglutinin and neuraminidase glycoproteins, of which there are 16 types and nine types, respectively. The major subtypes of influenza A that are currently circulating among people worldwide include H1N1 and H3N2 viruses. The risk of complications and death is greatly increased in previously unexposed young children and the elderly (>65 years), due to their reduced immune function. Interestingly, the majority of severe cases from the 2009 H1N1 pandemic were reported in children and young adults, while the elderly population was relatively protected from infection and severe diseas. This study provided detailed insights into the age-specific course at the early phase of infection in aged mice and lung pathology associated with severe influenza virus infection, as well as, the anti-M2e monoclonal antibody (rM2ss23) effect in preventing virus release from infected cells as a promising target candidate for antiviral drug design in highly immunogenic forms.

Contributors

Author:
Muto, Nilton

Further information

Media Type:
Taschenbuch
Publisher:
Novas Edicioes Academicas
Biography Artist:

Graduado em Biomedicina (2002) e Mestre em Biologia de Agentes Infecciosos e Parasitários pela Universidade Federal do Pará em (Conceito CAPES 5). Doutor em Virologia do Departamento de Patobiologia Molecular pela Universidade de Hokkaido, Japão. Atualmente, professor Adjunto da UFPA na área de Biotecnologia e Engenharia de Bioprocessos
Language:
Englisch
Number of Pages:
76

Master Data

Product Type:
Paperback book
Release date:
14 December 2017
Package Dimensions:
0.22 x 0.15 x 0.005 m; 0.159 kg
GTIN:
09786202043564
DUIN:
EBR8RC7AT3I
£31.99
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