Development of Novel Indolyl-derived Biologically Active Compounds - Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer)

by El Sayed, Mardia
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El Sayed, Mardia Development of Novel Indolyl-derived Biologically Active Compounds - Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer)
El Sayed, Mardia - Development of Novel Indolyl-derived Biologically Active Compounds - Synthesis, Characterization and Applications as (Anti-MRSA, Anticancer)

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Description

MRSA is a methicillin-resistance Staphylococcus aureus and a strain of Staphylococcus aureus that developed resistance to the killing effect of the beta-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, oxacillin, etc.), MRSA is sometimes called a "superbug" because it is very difficult to treat and it causes a huge number of infections every year in hospitals all over the world. The novel synthesized indoles will add a valuable new addition to the antibacterial arsenal for MRSA infections, it would be new bactericidal agents effective against resistant isolates or standard. We have shown for the first time that the cycloalkanoindoles,bis-indolobenzocarbazoles and the oxidized bis-indolylmethenes inhibited growth of drug resistant MRSA either standard or isolate and other Gram-positive bacteria at low concentrations. Some of these novel bis- and tris-indolyl compounds described in this work have been screened in the national cancer institute (NCI) in USA for one and five dose that showed the highest antipoliferative activity in a nanomolar scale towards the selected cancers cell lines (Non small lung: NCIeH460, Ovarian: OVCAR-4 and Breast: MCF).

Contributors

Author:
El Sayed, Mardia

Further information

Biography Artist:
Author is Dr/Mardia Telep El Sayed, Egyptian researcher at National Research Centre, Applied Organic Chemistry Department. In 2009 she started her PhD scholarship in Synthetic Organic Chemistry/ Martin Luthr University Halle/ Germany and recieved her PhD in April 2013. She has BSc and MSc in Organic Chemistry from Egyptian Universties.
Language:
Englisch
Number of Pages:
312
Media Type:
Taschenbuch
Publisher:
LAP Lambert Academic Publishing

Master Data

Product Type:
Paperback book
Release date:
07 April 2015
Package Dimensions:
0.22 x 0.15 x 0.018 m; 0.513 kg
GTIN:
09783659320712
DUIN:
CNHHO58NAQC
£76.99
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