Web 2.0 companies & banking giants like J.P. Morgan, Goldman Sachs and Morgan Stanley are facing issues in managing intense volume of data. Organisations are trying to migrate from traditional to more efficient & flexible solutions like NoSQL & Cloud computing. NoSQL solves the rudimentary challenge of storage & retrieval of high-volume transactional real time data & Cloud computing complements the prior with high on-demand network access to a shared pool of computing resources. Despite the ideal characteristics of NoSQL data stores as cloud data management systems & computing competence of shared access, it is difficult to comprehend an ideal domain specific architecture due to the high diversity of these solutions. The handbook reviews the paradigm of NoSQL Data Storage, Cloud Computing & Agile Development. Its goal is to leverage guidance to researchers and practitioners, helping them select the best-fit data store, identifying challenges & opportunities of the trending assimilated paradigm.