Novel Biosensors Using Intact Liposome Microarrays - Concept, Design, Fabrication and Testing of Membrane Protein and Receptor Based Biosensors

by Kalyankar, Nikhil
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Kalyankar, Nikhil Novel Biosensors Using Intact Liposome Microarrays - Concept, Design, Fabrication and Testing of Membrane Protein and Receptor Based Biosensors
Kalyankar, Nikhil - Novel Biosensors Using Intact Liposome Microarrays - Concept, Design, Fabrication and Testing of Membrane Protein and Receptor Based Biosensors

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Description

Many of the interactions studied in the biological and biomedical sciences occur with receptors at cell membrane surfaces. Prominent examples are neurotransmitters, cytokine receptors, tyrosine kinase receptors, ligang-and voltage-gated ion channels, G protein-coupled receptors, and antibody receptors. Interactions with these receptors are of special importance not only to academics, but also to the pharmaceutical industry as almost half of the 100 best-selling drugs on the market are targeted to a membrane receptor. More than 50% of current drug targets are membrane bound.Naturally, there is a great interest in development of sensors using membrane proteins for drug discovery and high-throughput screening for detection of pathogens/toxins. This book describes protocols to array individual, intact small unilamellar vesicles (liposomes) onto chemically modified microwell substrates. These arrays can be used as biosensors using membrane proteins or receptors incorporated in the lipid bilayer of the arrayed liposomes. One of the key examples covered in this work is the use of this platform to display GM1 ganglioside receptor to detect cholera toxin in analyte solutions.

Contributors

Author:
Kalyankar, Nikhil

Further information

Biography Artist:
Dr. Nikhil D Kalyankar received Bachelor of Chemical Engineering at UDCT Mumbai in 2002 and PhD in Chemical Engineering at The City University of New York in 2007. His research interests include Biosensors, Surface and Interfacial Science, Nanotechnology, Green Energy, Semiconductors etc. He is also a private pilot and lives in San Jose CA.
Language:
English
Number of Pages:
112
Media Type:
Softcover
Publisher:
VDM Verlag Dr. Müller

Master Data

Product Type:
Paperback book
Release date:
1 September 2009
Package Dimensions:
0.22 x 0.15 x 0.007 m; 0.213 kg
GTIN:
09783639189384
DUIN:
LV1PMMNI7AA
£41.44
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